Ethyl Acetoacetate → 3-Acetyl-7-methoxycoumarin

HRID 25873

Reaktionsgleichung

Reaktionsgleichung von HRID 25873
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:12](OCC)(=[O:17])[CH2:13][C:14]([CH3:16])=[O:15]>N1CCCCC1>[C:14]([C:13]1[C:12](=[O:17])[O:1][C:2]2[C:3]([CH:4]=1)=[CH:6][CH:7]=[C:8]([O:10][CH3:11])[CH:9]=2)(=[O:15])[CH3:16]

Komponenten

4

Edukt 2

HCID 8868Ethyl AcetoacetateHCID 696002-Hydroxy-4-Methoxybenzaldehyde

Produkt 1

HCID 20544753-Acetyl-7-methoxycoumarin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8082PiperidineKatalysator

Versuchsvorschrift

A mixture of 15.2 g 2-hydroxy-4-methoxybenzaldehyde and 13.5 g ethyl acetoacetate was warmed on a hot plate until solution was attained. Thirty drops of piperidine were added and the reaction mixture continued to be heated gently. After several minutes the reaction mixture solidified. After cooling, the product was recrystallized from a mixture of alcohol and acetonitrile. Yield 20 g.

Aufarbeitung

  1. temperaturewas warmed on a hot plate until solution
  2. temperatureto be heated gently
  3. waitAfter several minutes the reaction mixture solidified
  4. temperatureAfter cooling
  5. customthe product was recrystallized from a mixture of alcohol and acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-0dc7f5bd4b6b41e582a9b7b4128509d7
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04147552

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