Hydrochloric Acid → Suprofen

HRID 258902

Reaktionsgleichung

Reaktionsgleichung von HRID 258902
CC(N)C1C=CC=CC=1.[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1.Cl>O>[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 70638167(+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

Produkt 1

HCID 5359Suprofen

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1.5 Parts of (-)-p-(2-thenoyl)hydratropic acid α-methyl-benzylamine are suspended in water and acidified with hydrochloric acid. The product is extracted with ether. The organic layer is washed with water, dried and evaporated. The oily residue solidifies on triturating in petroleumether. The solified product is filtered off and dried in vacuo at 50° C, yielding (+)-p-(2-thenoyl)hydratropic acid; [α] (1% in MeOH) = +44.5°.

Aufarbeitung

  1. extractionThe product is extracted with ether
  2. washThe organic layer is washed with water
  3. customdried
  4. customevaporated
  5. customon triturating in petroleumether
  6. filtrationThe solified product is filtered off
  7. customdried in vacuo at 50° C

Quellen und Nachweise

ORD-Eintrag
ord-05456246330d4b0294a5e89fa2698254
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04035376

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