Water → HCID 178514091, Verbindung

HRID 258991

Reaktionsgleichung

Reaktionsgleichung von HRID 258991
Cl.[NH2:2][C@H:3]([C:6](O)=O)[CH2:4][SH:5].Br[CH2:10][CH2:11][NH:12][C:13]([NH2:15])=[O:14].[OH2:16]>>[NH:12]([CH2:11][CH2:10][CH2:6][C@@H:3]([C:4]([OH:16])=[S:5])[NH2:2])[C:13]([NH2:15])=[O:14]

Komponenten

4

Edukt 3

HCID 962Water3×HCID 60960Cysteine HydrochlorideHCID 2636101-(2-Bromoethyl)urea

Produkt 1

HCID 178514091HCID 178514091, Verbindung

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

26.25 g of cysteine hydrochloride and 27.83 g of β-bromoethylurea are dissolved in 150 cc of water under nitrogen. A solution of 13.35 g of soda in 30 cc of water is added during a 40 minute period and the mixture is heated for 3 hours at 50° C. After cooling, there is added to the solution, four times its volume of water and the resulting mixture is passed over a cation exchange resin. After washing with water, the product fixed on the resin is eluted with an ammoniacal solution. The eluate is evaporated to dryness and the residue is crystallized in an aqueous methanol solution. There are obtained 19.5 grams of the white product melting at 220° C with decomposition.

Aufarbeitung

  1. temperatureAfter cooling
  2. washAfter washing with water
  3. washis eluted with an ammoniacal solution
  4. customThe eluate is evaporated to dryness
  5. customthe residue is crystallized in an aqueous methanol solution

Quellen und Nachweise

ORD-Eintrag
ord-36c24f6c62de4ceeaa705f3de9047a49
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04035492

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