Diethyl Ether → 2-(7-Hydroxyheptyl)cyclopent-2-en-1-one

HRID 259194

Reaktionsgleichung

Reaktionsgleichung von HRID 259194
O1CCCCC1O[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]=[O:15].O1CCN(C2CCCC=2)CC1.[C:27]1(=[O:32])[CH2:31][CH2:30][CH2:29][CH2:28]1.C(OCC)C>C1C=CC=CC=1>[OH:32][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:8][CH2:9][C:10]1[C:14](=[O:15])[CH2:13][CH2:12][CH:11]=1

Komponenten

6

Edukt 4

HCID 3283Diethyl EtherHCID 8452CyclopentanoneHCID 702941-MorpholinocyclopenteneHCID 1821847-(Oxan-2-yloxy)heptanal

Produkt 1

HCID 205354882-(7-Hydroxyheptyl)cyclopent-2-en-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 7-(2-tetrahydropyranyloxy)heptanal (22 g.) and 1-morpholinocyclopentene, i.e. the morpholine enamine of cyclopentanone, (21.4 g.) in benzene (25 ml.) was heated under reflux for 12 hours under nitrogen, and the water liberated was continuously removed with a Dean and Stark head. Benzene (10 ml.) and then, dropwise, 18% hydrochloric acid (28 ml.) were added and the mixture was stirred for 2 hours. The organic layer was separated and evaporated. Concentrated hydrochloric acid (72 ml.) and butanol (300 ml.) were added to the residue. The mixture was heated at 100° C. for 1 hour, and then the solution was concentrated to give an oil. Diethyl ether was added, and the ether solution was washed with aqueous sodium bicarbonate and then water, and dried over sodium sulphate. The solvent was evaporated and the residue was distilled under reduced pressure to give 2-(7-hydroxyheptyl)cyclopent-2-en-1-one (11.7 g.), b.p. 125°-170° C./0.15 mm.Hg, nD25 1.490, λmax 228 mμ (ethanol).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 12 hours under nitrogen
  3. customthe water liberated was continuously removed with a Dean and Stark head
  4. additionBenzene (10 ml.) and then, dropwise, 18% hydrochloric acid (28 ml.) were added
  5. customThe organic layer was separated
  6. customevaporated
  7. additionConcentrated hydrochloric acid (72 ml.) and butanol (300 ml.) were added to the residue
  8. concentrationthe solution was concentrated
  9. customto give an oil
  10. washthe ether solution was washed with aqueous sodium bicarbonate
  11. dry with materialwater, and dried over sodium sulphate
  12. customThe solvent was evaporated
  13. distillationthe residue was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-53d99f4adce6431c814aba1fb40b4ad7
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04036872

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