Potassium cyanate → 2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea

HRID 259327Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 259327
Cl.[C:2]([C:5]1[S:9][C:8]2[CH2:10][CH2:11][CH2:12][CH:13]([NH2:14])[C:7]=2[CH:6]=1)(=[O:4])[CH3:3].[O-:15][C:16]#[N:17].[K+]>O>[C:2]([C:5]1[S:9][C:8]2[CH2:10][CH2:11][CH2:12][CH:13]([NH:14][C:16]([NH2:17])=[O:15])[C:7]=2[CH:6]=1)(=[O:4])[CH3:3]

Komponenten

4

Edukt 2

HCID 11378442Potassium cyanateHCID 203489702-Acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride

Produkt 1

HCID 203489892-Acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A sample of 6.3 grams of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride is dissolved in 35 ml. of water and cooled to 15° C. A solution of 2.64 grams of potassium cyanate in 35 ml. of water is added, and after 0.5 hour the mixture is heated at 70° C. for about 40 minutes. The mixture is cooled, and the solid is collected and washed with water. On drying, 5.55 grams, melting point 218° C. to 220° C., of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea is obtained.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. customthe solid is collected
  3. washwashed with water
  4. customOn drying

Quellen und Nachweise

ORD-Eintrag
ord-ebb256f5d1cc42ff8f61ea1f58be55f2
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04036979

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