Hydrogen Peroxide → Chalcone epoxide

HRID 259431

Reaktionsgleichung

Reaktionsgleichung von HRID 259431
[CH:1](=[CH:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:17]O.[OH-].[Na+]>CO>[C:2]1([C:1](=[O:17])[CH:8]2[O:10][CH:9]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 784Hydrogen PeroxideHCID 7189CinnamoylbenzeneHCID 14798Sodium Hydroxide

Produkt 1

HCID 92219Chalcone epoxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a mechanically stirred mixture of 83.2 g benzalacetophenone (0.3m), 1000 ml methanol and 120 ml 15% hydrogen peroxide was added 100 ml 2N sodium hydroxide solution, while maintaining the temperature below 30° by external cooling. After completed addition, the mixture was left standing at room temperature for 20 min. The crystalline precipitate was filtered off, washed with water and recrystallized from methanol. There were obtained 59.6 g 1,3-diphenyl-2,3-epoxy-1-propanone; m.p. 90° C.

Aufarbeitung

  1. temperaturewhile maintaining the temperature below 30° by external cooling
  2. additionaddition
  3. waitthe mixture was left
  4. filtrationThe crystalline precipitate was filtered off
  5. washwashed with water
  6. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-81b9796c644749a9b95c4d65aec2b733
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04038289

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