Pyridine → 3-Benzoylamino-5-nitro-2-pyridone

HRID 259551Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 259551
[NH2:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.N1C=CC=CC=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O>[C:18]([NH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 7412Benzoyl chlorideHCID 227547823-Amino-5-nitropyridin-2(1H)-one

Produkt 1

HCID 227547673-Benzoylamino-5-nitro-2-pyridone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 100 mg. of 3-amino-5-nitro-2-pyridone in 1.5 ml. of pyridine was cooled and treated with 200 mg. of benzoyl chloride. After 2 hours water was added. The oil that separated was washed with water and triturated with ether. The resultant solid was recrystallized from ethyl acetate to give 3-benzoylamino-5-nitro-2-pyridone, m.p. 267°-268° C.

Aufarbeitung

  1. additiontreated with 200 mg
  2. customThe oil that separated
  3. washwas washed with water
  4. customtriturated with ether
  5. customThe resultant solid was recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-079b0e23338641ffac98174dfa2c9a3f
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04038396

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