1-Benzyl-4-piperidone → N~1~-(1-Benzylpiperidin-4-yl)-N~2~-phenylethane-1,2-diamine

HRID 25970

Reaktionsgleichung

Reaktionsgleichung von HRID 25970
[C:1]1([NH:7][CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:11]([N:18]1[CH2:23][CH2:22][C:21](=O)[CH2:20][CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C([BH3-])#N.[Na+]>CO.Cl>[CH2:11]([N:18]1[CH2:23][CH2:22][CH:21]([NH:10][CH2:9][CH2:8][NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:20][CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

6

Edukt 3

HCID 192201-Benzyl-4-piperidoneHCID 742701,2-Ethanediamine, N1-phenyl-HCID 5003444Sodium cyanoborohydride

Produkt 1

HCID 20540168N~1~-(1-Benzylpiperidin-4-yl)-N~2~-phenylethane-1,2-diamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To the solution of 12.6 g of N-phenylethylenediamine in 200 ml of methanol, 50 ml of 4.1 N ethanolic hydrogen chloride are added dropwise followed by 18.9 g of 1-benzyl-4-piperidone in 100 ml of methanol. Then, 9.45 g sodium cyanoborohydride are added in portions while stirring at room temperature. After 72 hours the mixture is filtered, the residue dissolved in water and the solution made basic with 12.5% aqueous sodium hydroxide. It is extracted with methylene chloride, dried and evaporated to yield the 1-benzyl-4-(2-phenylaminoethylamino)-piperidine.

Aufarbeitung

  1. filtrationAfter 72 hours the mixture is filtered
  2. dissolutionthe residue dissolved in water
  3. extractionIt is extracted with methylene chloride
  4. customdried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e571c060f05d484fa41ce6089969dd32
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04147786

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