Htris → 2-(2-Isopropyl-5-indanyl)propionic acid

HRID 261525

Reaktionsgleichung

Reaktionsgleichung von HRID 261525
[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:13](=[CH2:17])[C:14]([OH:16])=[O:15])[CH:10]=2)[CH2:5]1)([CH3:3])[CH3:2].OCC([NH3+])(CO)CO>C(O)C.[Pt](=O)=O>[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:10]=2)[CH2:5]1)([CH3:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 3777159HtrisHCID 542342992-Isopropyl-alpha-methylene-5-indanacetic acid

Produkt 1

HCID 687692-(2-Isopropyl-5-indanyl)propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 1.7 g of 2-isopropyl-α-methylene-5-indanacetic acid in 300 cc of ethanol is hydrogenated at room temperature with the addition of 50 mg of platinum(IV) oxide. After filtering off the catalyst, removing the solvent by evaporation and chromatographing the resulting oil, 2-isopropyl-α-methyl-5-indanacetic acid, having a M.P. of 83°-86°, is obtained. The (1,3-dihydroxy-2-hydroxymethyl-2-propyl)ammonium salt of the title compound has a M.P. of 140°-141° (from methanol/ether).

Aufarbeitung

  1. filtrationAfter filtering off the catalyst
  2. customremoving the solvent
  3. customby evaporation and chromatographing the resulting oil, 2-isopropyl-α-methyl-5-indanacetic acid
  4. customis obtained

Quellen und Nachweise

ORD-Eintrag
ord-df1cdc89f3144844b82437d920b8d357
Quelldatensatz
uspto-grants-1979_08
Patentnummer
US04166131

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