Metaperiodic acid → 3-Chloro-4-cyclohexylbenzaldehyde

HRID 261586

Reaktionsgleichung

Reaktionsgleichung von HRID 261586
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([OH:17])CO)[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.I(O)(=O)(=O)=O>O1CCCC1.CCOCC>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1)[CH:14]=[O:17]

Komponenten

5

Edukt 2

HCID 65185Metaperiodic acidHCID 129398511-(3-Chloro-4-cyclohexylphenyl)ethane-1,2-diol

Produkt 1

HCID 107277773-Chloro-4-cyclohexylbenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 115 g. of 1-(3-chloro-4-cyclohexylphenyl)-1,2-ethanediol in tetrahydrofuran (800 ml.) is added a solution of periodic acid (102 g.) in ether (750 ml.). The reaction mixture is stirred under nitrogen overnight. The reaction mixture is filtered and the filtrate is washed with water (3×200 ml) and placed over sodium sulfate. Removal of solvent gives a liquid residue which is then distilled to give 3-chloro-4-cyclohexylbenzaldehyde.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered
  2. washthe filtrate is washed with water (3×200 ml)
  3. customRemoval of solvent
  4. customgives a liquid residue which
  5. distillationis then distilled

Quellen und Nachweise

ORD-Eintrag
ord-bd3d48e15ff34669857d860640d41bc3
Quelldatensatz
uspto-grants-1979_08
Patentnummer
US04166133

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