UP 614-04 → 2-(1-Phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate

HRID 261786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 261786
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][N:15]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[N:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:16]2=[O:30])[CH2:9]1)C1C=CC=CC=1.Cl.CN1C2C=CC=CC=2N(CC2OCCNC2)C1=O.[C:50]([OH:57])(=[O:56])/[CH:51]=[CH:52]\[C:53]([OH:55])=[O:54]>C(O)(C)C>[C:50]([OH:57])(=[O:56])/[CH:51]=[CH:52]\[C:53]([OH:55])=[O:54].[C:24]1([N:17]2[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[N:15]([CH2:14][CH:10]3[O:11][CH2:12][CH2:13][NH:8][CH2:9]3)[C:16]2=[O:30])[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Komponenten

5

Edukt 3

HCID 134375UP 614-04HCID 444266Maleic AcidHCID 706018204-Benzyl-2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine

Produkt 1

HCID 867360832-(1-Phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel2×

Versuchsvorschrift

18 g of 4-benzyl-2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine are treated as in part (a) of Example 2. After evaporation of the solvent under reduced pressure, 15 g of an oily product are obtained and are dissolved in hot isopropyl alcohol. A hot solution of maleic acid in isopropanol is added. The salt precipitates slowly. 16.5 g of 2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate are obtained, m.p. 200° C.

Aufarbeitung

  1. customAfter evaporation of the solvent under reduced pressure, 15 g of an oily product
  2. customare obtained
  3. customThe salt precipitates slowly

Quellen und Nachweise

ORD-Eintrag
ord-407ff9eee7264ce1a915aedfde839f02
Quelldatensatz
uspto-grants-1979_05
Patentnummer
US04152434

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