Ammonia → (4-bromophenyl)(1H-imidazol-2-yl)phenylmethanol

HRID 261931

Reaktionsgleichung

Reaktionsgleichung von HRID 261931
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:10]2[N:11](S(C3C=CC(C)=CC=3)(=O)=O)[CH:12]=[CH:13][N:14]=2)[OH:9])=[CH:4][CH:3]=1.Cl.N>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)([C:10]2[NH:14][CH:13]=[CH:12][N:11]=2)[OH:9])=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 11838798alpha-(p-Bromophenyl)-alpha-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol

Produkt 1

HCID 12433864(4-bromophenyl)(1H-imidazol-2-yl)phenylmethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 24.8 g. (0.052 mol) of α-(p-bromophenyl)-α-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol, 160 ml. of 2 N hydrochloric acid solution (0.156 mol) and about 500 ml. of water was boiled under reflux for 5 hours. After cooling the mixture was made alkaline by addition of ammonia. The precipitated solid was collected, treated with activated carbon in boiling toluene and crystallised from toluene. Melting point of the product was 156°-158° C.

Aufarbeitung

  1. additionA mixture of 24.8 g
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling the mixture
  4. customThe precipitated solid was collected
  5. additiontreated with activated carbon
  6. customcrystallised from toluene
  7. customwas 156°-158° C.

Quellen und Nachweise

ORD-Eintrag
ord-26d17c2475ad44a4a697a698d7e18002
Quelldatensatz
uspto-grants-1979_05
Patentnummer
US04152441

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