N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester → N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine

HRID 262273

Reaktionsgleichung

Reaktionsgleichung von HRID 262273
C([O:8][C:9](=[O:22])[C@H:10]([CH3:21])[NH:11][C:12](=[O:20])[CH:13]([CH3:19])[CH2:14][C:15]([O:17][CH3:18])=[O:16])C1C=CC=CC=1>C(O)C.[Pd]>[CH3:18][O:17][C:15]([CH2:14][CH:13]([CH3:19])[C:12]([NH:11][C@H:10]([C:9]([OH:22])=[O:8])[CH3:21])=[O:20])=[O:16]

Komponenten

4

Edukt 1

HCID 53826083N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester

Produkt 1

HCID 53969800N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine benzyl ester (50 g.) is dissolved in 95% ethanol, 10% palladium on charcoal (5 g.) is added and the mixture is hydrogenated at normal pressure for 16 hours. The catalyst is filtered off and the filtrate is concentrated to dryness in vacuo to yield N-(3-methoxycarbonyl-2-methylpropanoyl)-L-alanine.

Aufarbeitung

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1ef4074e094e4767be54b6061fe62c15
Quelldatensatz
uspto-grants-1979_05
Patentnummer
US04153725

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