Hydrazine hydrate (1:1) → 2-[(4-Methylpiperazin-1-yl)methyl]aniline

HRID 262328

Reaktionsgleichung

Reaktionsgleichung von HRID 262328
O.NN.[CH3:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)[CH2:7][CH2:6]1>C(O)C.[Ni]>[CH3:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])[CH2:7][CH2:6]1

Komponenten

5

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 7913741-Methyl-4-(2-nitrobenzyl)piperazine

Produkt 1

HCID 64845562-[(4-Methylpiperazin-1-yl)methyl]aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In 30 volume parts of ethanol is dissolved 1.87 parts of N1 -methyl-N4 -(2-nitrobenzyl)piperazine, followed by the addition of 3.0 parts of Raney nickel. Then, 3.0 parts of hydrazine hydrate is further added to the mixture and the entire mixture is kept at room temperature for 2 hours. Following this reaction, the Raney nickel is filtered off and the solvent is distilled off under reduced pressure. The residual oily substance is recrystallized from aqueous methanol. The procedure gives pale yellow crystals melting at 78° to 79° C.

Aufarbeitung

  1. customthis reaction
  2. filtrationthe Raney nickel is filtered off
  3. distillationthe solvent is distilled off under reduced pressure
  4. customThe residual oily substance is recrystallized from aqueous methanol

Quellen und Nachweise

ORD-Eintrag
ord-95c8fb53c13d473a95aa0562f28fc929
Quelldatensatz
uspto-grants-1979_05
Patentnummer
US04153794

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