Formaldehyde → (1,4-dimethyl-1H-imidazol-2-yl)methanol
Reaktionsgleichung
[CH2:1]([Li])[CH2:2][CH2:3]C.C=O.[OH:8][CH2:9][C:10]1[N:14]2CCCCC2=[CH:12][N:11]=1>>[CH3:12][N:11]1[CH:3]=[C:2]([CH3:1])[N:14]=[C:10]1[CH2:9][OH:8]Komponenten
4
Versuchsvorschrift
The reaction of 1,4-dimethylamidazole (5.65 g.) with n-butyl lithium followed by treatment with formaldehyde (according to the method described for the preparation of 3-hydroxymethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine in Example 243) gave 1,4-dimethyl-2-hydroxymethylimidazole (2.71 g.), m.p. 125°-126° (ethyl acetate-petroleum ether).
Quellen und Nachweise
- ORD-Eintrag
- ord-600d33573d3948dab7ef1f782a87ba80
- Quelldatensatz
- uspto-grants-1979_05
- Patentnummer
- US04154844
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