Ethanol → 1-(2,6-Dichlorobenzylideneamino)-3-(2-thenyl)guanidine

HRID 262768

Reaktionsgleichung

Reaktionsgleichung von HRID 262768
I.[Cl:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:4]=1[CH:5]=[N:6][NH:7][C:8](=[NH:11])SC.[NH2:17][CH2:18][C:19]1[S:20][CH:21]=[CH:22][CH:23]=1.C(O)C>O.[OH-].[Na+]>[Cl:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:4]=1[CH:5]=[N:6][NH:7][C:8]([NH:17][CH2:18][C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)=[NH:11]

Komponenten

6

Edukt 3

HCID 702EthanolHCID 34005(2-Thienylmethyl)amineHCID 178504060Methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydroiodide

Produkt 1

HCID 1785121161-(2,6-Dichlorobenzylideneamino)-3-(2-thenyl)guanidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A solution of 5.85 g. of methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydriodide and 3.39 g. of 2-(aminomethyl)thiophene in 25 ml. of absolute ethanol is heated under reflux for 16 hours, diluted with water and excess 10N sodium hydroxide is added. After standing, crystallization occurs, and filtration gives 3.50 g. of nearly colorless crystals. Recrystallization from aqueous ethanol gives the desired product as colorless crystals, m.p. 135°-137° C.

Aufarbeitung

  1. temperatureunder reflux for 16 hours
  2. additionis added
  3. customcrystallization
  4. filtrationfiltration
  5. customgives 3.50 g
  6. customRecrystallization from aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-99cc69d1626a41b6ac9ae6c77d9a89d0
Quelldatensatz
uspto-grants-1979_05
Patentnummer
US04154947

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