HCID 22218187, Verbindung → 3-methanesulfonyl-2-methylpropanoic acid

HRID 263474Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 263474
[CH3:1][S:2]([CH2:5][C:6](=[CH2:10])[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]>CO.[Pd]>[CH3:10][CH:6]([CH2:5][S:2]([CH3:1])(=[O:4])=[O:3])[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 1

HCID 22218187HCID 22218187, Verbindung

Produkt 1

HCID 221423443-methanesulfonyl-2-methylpropanoic acidAusbeute 96,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2-(methylsulfonylmethyl) acrylic acid (700 mg, 4.26 mmol) in 20 mL of methanol was charged into a Fisher-Porter bottle along with 10% palladium on carbon catalyst under a nitrogen atmosphere. The reaction vessel was sealed and flushed five times with nitrogen and then five times with hydrogen. The pressure was maintained at 50 psig for 16 hours and then the hydrogen was replaced with nitrogen and the solution filtered through a pad of celite to remove the catalyst and the filterate concentrated in vacuo to give 682 mg 96% of 2-(R,S)-methyl-3-methylsulfonyl propionic acid; formula: ##STR79##

Aufarbeitung

  1. customThe reaction vessel was sealed
  2. customflushed five times with nitrogen
  3. temperatureThe pressure was maintained at 50 psig for 16 hours
  4. filtrationthe solution filtered through a pad of celite
  5. customto remove the catalyst
  6. concentrationthe filterate concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5b3f4ebc12e547539ca51f1c83076f3c
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05643924

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