Sodium Cyanide → 4-amino-1-methylpiperidine-4-carbonitrile

HRID 264019Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 264019
[OH-].[NH4+:2].[Cl-].[NH4+:4].[C-:5]#N.[Na+].[CH3:8][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=O>>[NH2:2][C:12]1([C:5]#[N:4])[CH2:13][CH2:14][N:9]([CH3:8])[CH2:10][CH2:11]1

Komponenten

5

Edukt 4

HCID 8929Sodium CyanideHCID 13603N-Methyl-2-piperidoneHCID 14923Ammonium HydroxideHCID 25517Ammonium Chloride

Produkt 1

HCID 114349914-amino-1-methylpiperidine-4-carbonitrile

Versuchsvorschrift

Using the procedure of Stage 1 of Example 1, 8 ml of ammonium hydroxide, 1.58 g of ammonium chloride and 1.23 g of sodium cyanide were reacted and 2.5 ml of 1-methylpiperidone were added. The mixture was stirred for 18 hours at ambient temperature, followed by extraction r3 times with chloroform. The organic phase was washed with salt water and dried to obtain 2.41 g of the expected product (orange-yellow syrup).

Aufarbeitung

  1. customwere reacted
  2. extractionfollowed by extraction r3 times with chloroform
  3. washThe organic phase was washed with salt water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dc5971b1cb52476e8660ccef912bd5c0
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05646172

Notizen zur Reaktion

Wird geladen…