Ethanol → HCID 178507684, Verbindung

HRID 26438

Reaktionsgleichung

Reaktionsgleichung von HRID 26438
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[C:4]([Cl:9])[N:3]=1.C([OH:12])C.ClC1C=CC=C(C(OO)=O)C=1.[OH-].[Na+]>O>[NH2:1][C:2]1[N+:7]([O-:12])=[C:6]([NH2:8])[CH:5]=[C:4]([Cl:9])[N:3]=1

Komponenten

6

Edukt 4

HCID 702Ethanol2×HCID 14798Sodium HydroxideHCID 674322,4-Diamino-6-chloropyrimidineHCID 70297m-Chloroperbenzoic acid

Produkt 1

HCID 178507684HCID 178507684, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

75 G. of 2,4-diamino-6-chloropyrimidine are dissolved in 1500 ml. of ethanol at 35° C. The solution is cooled to -10° C. and a solution of 100 g. of 3-chloroperbenzoic acid in 500 ml. of ethanol is slowly added dropwise in the course of 1 hour. The suspension is subsequently stirred at -10° C. for 7 hours and left to stand at 5° C. overnight. The suspension is neutralized with 24 g. of sodium hydroxide in 100 ml. of water. The solid material is filtered off and recrystallized from ethanol, there being obtained pure 2,4-diamino-6-chloropyrimidine-3-oxide.

Aufarbeitung

  1. customat 35° C
  2. waitleft
  3. waitto stand at 5° C. overnight
  4. filtrationThe solid material is filtered off
  5. customrecrystallized from ethanol, there

Quellen und Nachweise

ORD-Eintrag
ord-b5b5bfbf4734491189729b6f78233366
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04150132

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