Reaktionsgleichung
[Na].[OH:2][CH2:3][C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1.C[O:11][C:12](=O)[CH:13]([C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([CH3:24])[CH3:23])=[CH:17][CH:16]=1)[CH3:14]>O>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([CH2:3][O:2][C:12](=[O:11])[CH:13]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([CH3:24])[CH3:23])=[CH:17][CH:16]=2)[CH3:14])[CH:5]=1Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 0.05 g of sodium and 8 ml of 3-hydroxymethylpyridine was heated at 65°-70° C. for 10 hours. To this mixture was added 3.8 g of 2-(p-isobutylphenyl)propionic acid methyl ester, and the whole was heated at 95°-100° C. for 8 hours. After cooling to room temperature, 100 ml of water was added. The resulting mixture was extracted with ether, and the ether was distilled away from the extract to leave a residue. The residue was passed through a column of silica gel, and the adsorbate was eluted with chloroform. The eluates were freed of chloroform in vacuo to give 2.9 g of 2-(p-isobutylphenyl)propionic acid-3-pyridylmethyl ester as a colorless oil. The infrared spectrum showed strong C=O absorption at 1730 cm-1 characteristic for ester. Mass spectrum: parent ion 297 m/e.
Aufarbeitung
- temperaturewas heated at 65°-70° C. for 10 hours
- temperaturethe whole was heated at 95°-100° C. for 8 hours
- extractionThe resulting mixture was extracted with ether
- distillationthe ether was distilled away from the
- extractionextract
- customto leave a residue
- washthe adsorbate was eluted with chloroform
Quellen und Nachweise
- ORD-Eintrag
- ord-bc15c9be271a4f4ab0bdbd78f546b8e4
- Quelldatensatz
- uspto-grants-1979_04
- Patentnummer
- US04150137
Verknüpfte Notizen
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