Lithium hydroxide, monohydrate → HCID 178440099, Verbindung
Reaktionsgleichung
[OH:1][CH:2]([C:4]1[N:5]=[C:6]([CH2:32][CH2:33][CH3:34])[N:7]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:8]=1[C:9]([O:11]CC)=[O:10])[CH3:3].O.[OH-].[Li+]>>[OH:1][CH:2]([C:4]1[N:5]=[C:6]([CH2:32][CH2:33][CH3:34])[N:7]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:8]=1[C:9]([OH:11])=[O:10])[CH3:3]Komponenten
3
Versuchsvorschrift
Following a procedure similar to that described in Example 36. 0.82 g of ethyl 4-(1-hydroxyethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 40(c)] was hydrolyzed using 0.43 g of lithium hydroxide monohydrate, to give 0.50 g of the title compound as a powder, melting at 198°-201° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-37159aff47e444d4b91b91e8dd6fa4af
- Quelldatensatz
- uspto-grants-1997_07