1-Indanone → 2,3-Dihydro-N-benzyl-1H-inden-1-amine

HRID 265228

Reaktionsgleichung

Reaktionsgleichung von HRID 265228
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.BrCC(OCC)=O>[Pd]>[CH:1]1([NH:18][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 67351-IndanoneHCID 7504BenzylamineHCID 7748Ethyl bromoacetate

Produkt 1

HCID 101307242,3-Dihydro-N-benzyl-1H-inden-1-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

The amino acid was synthesized as described by Miyake, et al., Takeda Kenkyushoho 44: 171-185 (1985). [Chem. Abstr. 106: 156830 (1987)]. N-(1-indanyl)-benzylamine was prepared by reductive amination of 1-indanone with benzylamine, and alkylation of the amine by ethyl bromoacetate. The benzyl group was cleaved by hydrogenolysis over palladium. Saponification of the ethyl ester gave the amino acid, which was converted to the Boc derivative by the standard procedure described in Example III.

Aufarbeitung

  1. customThe amino acid was synthesized

Quellen und Nachweise

ORD-Eintrag
ord-7f2f1b591a2445f18913943b894b5a90
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05648336

Verknüpfte Notizen

Wird geladen…