(+-)-Homocysteine → Captopril

HRID 265424

Reaktionsgleichung

Reaktionsgleichung von HRID 265424
N[C@@H](CCC(N[C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=O)C(O)=O.N[C@H:22]([C:25](O)=O)[CH2:23]S.N[CH:29](C(O)=O)CCS.CN(C1C=CC2N=C3C(=CC(C=C3)=[N+](C)C)SC=2C=1)C.C(N[C@H](C(O)=O)CS)(=O)C>>[CH3:29][C@@H:11]([C:14]([N:16]1[C@H:17]([C:18]([OH:20])=[O:19])[CH2:25][CH2:22][CH2:23]1)=[O:15])[CH2:12][SH:13]

Komponenten

6

Versuchsvorschrift

Glutathione, L-cysteine, DL-homocysteine, D-penicillin, hemoglobin (bovine), methylene blue and Medium 199 sets were purchased from Sigma Chemical Co., St. Louis, Mo. N-acetylcysteine was obtained from Aldrich Chemical Co., Milwaukee, Wis. Captopril was kindly provided by Dr Victor Dzau. Sodium nitrite, histamine and methacholine were purchased from Fisher Scientific, Fairlawn, N.J. Leukotriene D4 was purchased from Anaquest, BOC Inc., Madison, Wis. Antibiotic/antimycotic mixture (10,000 U/ml penicillin G sodium, 10,000 mcg/ml, streptomycin sulfate, 25 mcg/ml amphotericin B) was purchased from Gibco Laboratories, Grand Island, N.Y. Radioimmunoassay kits for the determination of cyclic GMP were purchased from New England Nuclear, Boston, Mass.

Quellen und Nachweise

ORD-Eintrag
ord-917876e8c76a4820a83b0d3ea7aed6f6
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05648393

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