Sodium Hydroxide → 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 22-3 (700 mg, 2.2 mmol), 1N NaOH, and ethanol (10 mL) was heated at 40° C. for 4 hours. The cooled reaction mixture was acidified with 10% KHSO4 and then extracted with EtOAc. The organic portion was washed with brine, dried (MgSO4) and concentrated to give 22-4 as a white solid. TLC Rf =0.80 (silica, 10:0.5:0.5 CH2Cl2 /CH3OH/AcOH);

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