反应详情

温度

40 °C

A mixture of 22-3 (700 mg, 2.2 mmol), 1N NaOH, and ethanol (10 mL) was heated at 40° C. for 4 hours. The cooled reaction mixture was acidified with 10% KHSO4 and then extracted with EtOAc. The organic portion was washed with brine, dried (MgSO4) and concentrated to give 22-4 as a white solid. TLC Rf =0.80 (silica, 10:0.5:0.5 CH2Cl2 /CH3OH/AcOH);

1. customThe cooled reaction mixture
2. extractionextracted with EtOAc
3. washThe organic portion was washed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated