Water → Tetrahydroquinoxaline bis(chloroacetamide)

Temperatur

0 °C

To a 1 L three-necked round bottomed flask equipped with a magnetic stir bar, reflux condenser and addition funnel, was added chloroacetyl chloride (9.6 mL, 0.120 mol) and CHCl3 (100 mL). The addition funnel was charged with a solution of tetrahydroquinoxaline (8.0 g, 0.0596 mol) and triethylamine (20.8 mL) in CHCl3 (100 mL). The flask was chilled to 0° C., and the amine was slowly added to the acid chloride. After the addition was complete, the mixture was allowed to warm to ambient temperature and stir for 1 hour. The flask was then cooled to 0° C. and H2O (50 mL) was slowly added. The mixture was diluted with CHCl3 (250 mL) and the layers were separated. The organic layer was washed with H2O (50 mL), 0.05N NaOH (2×50 mL), H2O (50 mL), 1N HCl (3×50 mL) and H2O (2×50 mL), and was dried over anhydrous Na2SO4. The solution was filtered and concentrated to a brown solid. The solid was collected by filtration, washed with 2-propanol (2×30 mL) and diethylether (2×40 mL) and dried to yield the title product (4.41 g, 51.5%). 1H NMR (DMSO-d6): δ 3.89 (s, 4 H), 4.01 (s, 4 H), 7.25 (s, 2 H), 7.65 (br s, 2 H).

1. customTo a 1 L three-necked round bottomed flask equipped with a magnetic stir bar
2. temperaturereflux
3. additioncondenser and addition funnel
4. additionAfter the addition
5. temperatureto warm to ambient temperature
6. temperatureThe flask was then cooled to 0° C.
7. customthe layers were separated
8. washThe organic layer was washed with H2O (50 mL), 0.05N NaOH (2×50 mL), H2O (50 mL), 1N HCl (3×50 mL) and H2O (2×50 mL)
9. dry with materialwas dried over anhydrous Na2SO4
10. filtrationThe solution was filtered
11. concentrationconcentrated to a brown solid
12. filtrationThe solid was collected by filtration
13. washwashed with 2-propanol (2×30 mL) and diethylether (2×40 mL)
14. customdried

ORD-Eintrag

ord-3df0456a7ca74d57b237eb52670e29ae

Quelldatensatz

uspto-grants-1997_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05650133