2-Aminopyridine → 2-Methylimidazo[1,2-a]pyridine

HRID 266058

Reaktionsgleichung

Reaktionsgleichung von HRID 266058
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][C:9](C1C=CC=C(C2C=CC(CC3C(CCCC)=NN4CCCCC=34)=CC=2)C=1C([O-])=O)(C)[CH3:10].BrCC(=O)C>CC(C)=O>[CH3:10][C:9]1[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]2[CH:8]=1

Komponenten

5

Edukt 3

HCID 104392-AminopyridineHCID 11715BromoacetoneHCID 1317201001,1-Dimethylethyl4'-[(2-butyl4,5,6,7-tetrahydro pyrazolo(1,5-a)pyridin-3-yl)methyl](1,1-biphenyl)2-carboxylate

Produkt 1

HCID 1367422-Methylimidazo[1,2-a]pyridineAusbeute 245,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

A mixture of 5 g of 2-amino pyridine and 250 ml of acetone were added at ambient temperature to a mixture of 7.25 g of 1 bromo 2-propanone and 20 ml of acetone and the mixture was refluxed for 30 minutes. Using the procedure of Stage C of Example 22, 5.3 g of the expected product were obtained in the form of an orange oil.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 30 minutes

Quellen und Nachweise

ORD-Eintrag
ord-62a8dbba62a849dea444fa303423e856
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05650414

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