Trifluoroacetic acid → [2-Benzothiazolyl][1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl]methanone

HRID 266084

Reaktionsgleichung

Reaktionsgleichung von HRID 266084
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)=[O:11].C(C(O)=O)(F)(F)F.[F:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH2:33]Br)=[CH:28][CH:27]=1.[OH-].[Na+]>[Br-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl.O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([CH:12]1[CH2:17][CH2:16][N:15]([CH2:33][CH2:32][C:29]2[CH:30]=[CH:31][C:26]([F:25])=[CH:27][CH:28]=2)[CH2:14][CH2:13]1)=[O:11]

Komponenten

8

Edukt 4

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 5731534-Fluorophenethyl bromideHCID 152370094-(Benzthiazole-2-carbonyl)piperidine

Produkt 1

HCID 15337459[2-Benzothiazolyl][1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl]methanone

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 165294Benzyltriethylammonium bromideKatalysatorHCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Mix (2-benzothiazolyl)(4-piperidinyl)methanone.CF3CO2H (1.95 g, 5.43 mmol), 2-(4-fluorophenyl)ethyl bromide (1.70 g, 8.35 mmol), benzyltriethylammonium bromide (149 mg, 0.54 mmol), sodium hydroxide (5 g), water (25 mL) and methylene chloride (25 mL). Stir at room temperature under an argon atmosphere overnight, then heat at reflux overnight. Cool the reaction to room temperature, separate the organic phase and extract the aqueous phase with methylene chloride (50 mL). Combine the organic phases, dry (Na2SO4) and evaporate the solvent in vacuo. Purify by chromatography (20% ethyl acetate/hexane with 2% triethylamine) and recrystallize (hexane) to give the title compound as pale yellow needles; mp 97°-98° C.

Aufarbeitung

  1. temperatureheat
  2. temperatureat reflux overnight
  3. temperatureCool
  4. customthe reaction to room temperature
  5. customseparate the organic phase
  6. extractionextract the aqueous phase with methylene chloride (50 mL)
  7. dry with materialCombine the organic phases, dry (Na2SO4)
  8. customevaporate the solvent in vacuo
  9. customPurify by chromatography (20% ethyl acetate/hexane with 2% triethylamine)
  10. customrecrystallize (hexane)

Quellen und Nachweise

ORD-Eintrag
ord-2986c784a7864d1d83e439765f4be730
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05650416

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