Propargyl bromide → 7-(2-Propyn-1-yloxy)-2H-1-benzopyran-2-one
Reaktionsgleichung
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[CH2:13](Br)[C:14]#[CH:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:15]([O:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1)[C:14]#[CH:13]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In 100 ml DMF at 70° C. for 12 hours, 0.1 mole 7-hydroxy-coumarin is reacted with 0.1 mole propargyl bromide in the presence of 0.1 mole potassium carbonate. The compound of the title is obtained at a 60% yield. This compound melts at 118° C.
Aufarbeitung
- customThe compound of the title is obtained at a 60% yield
Quellen und Nachweise
- ORD-Eintrag
- ord-65bf7f0d4bdc4cc0983572099323cd68
- Quelldatensatz
- uspto-grants-1979_04
- Patentnummer
- US04151291
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