HCID 86746276, Verbindung → N2 [3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1-tert.butyl-4(S)-hydroxy-L-prolinamide

HRID 267157Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 267157
[N:1]#[N:2].C(OC([NH:13][C@@H:14]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C@H:15]([OH:30])[CH2:16][C@@:17]1([C:27]([NH2:29])=[O:28])[CH2:21][C@H:20]([OH:22])[CH2:19][N:18]1[C:23]([CH3:26])([CH3:25])[CH3:24])=O)C1C=CC=CC=1>C(O)C.[Pd]>[N:1]#[N:2].[NH2:13][C@@H:14]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C@H:15]([OH:30])[CH2:16][C@@:17]1([C:27]([NH2:29])=[O:28])[CH2:21][C@H:20]([OH:22])[CH2:19][N:18]1[C:23]([CH3:26])([CH3:24])[CH3:25]

Komponenten

4

Edukt 1

HCID 86746276HCID 86746276, Verbindung

Produkt 1

HCID 86746274N2 [3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1-tert.butyl-4(S)-hydroxy-L-prolinamideAusbeute 98,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

0.11 g of N2 -[3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-4(S)-hydroxy-L-prolinamide was dissolved in 10 ml of ethanol and hydrogenated over 20 mg of 10% palladium-on-carbon at room temperature and under atmospheric pressure for 2 hours. The catalyst was filtered off and the filtrate was evaporated to give 0.08 g of N2 -[3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-4(S)-hydroxy-L-prolinamide as a gum which was used without further purification.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-286454ae2653461684054c7e1d5c0222
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05652369

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