Dimethylcarbamoyl Chloride → alpha-Diethylcarbamylthio-2'-chloro-4-biphenylylacetic acid

HRID 267397

Reaktionsgleichung

Reaktionsgleichung von HRID 267397
[CH2:1]([N:3]([CH2:7][CH3:8])[C:4](Cl)=[O:5])[CH3:2].C(Cl)(=O)N.C(NC(Cl)=O)C.CN(C)C(Cl)=O.C([S:28][CH:29]([C:33]1[CH:38]=[CH:37][C:36]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[Cl:45])=[CH:35][CH:34]=1)[C:30]([OH:32])=[O:31])(=O)N.C(NC(SC(C1C=CC(C2C=CC=CC=2Cl)=CC=1)C(O)=O)=O)C.CN(C)C(SC(C1C=CC(C2C=CC=CC=2Cl)=CC=1)C(O)=O)=O>>[CH2:1]([N:3]([CH2:7][CH3:8])[C:4]([S:28][CH:29]([C:33]1[CH:38]=[CH:37][C:36]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[Cl:45])=[CH:35][CH:34]=1)[C:30]([OH:32])=[O:31])=[O:5])[CH3:2]

Komponenten

8

Edukt 7

HCID 6598Dimethylcarbamoyl ChlorideHCID 6916Diethylcarbamoyl chlorideHCID 68048Carbamic chlorideHCID 12321963N-ethylcarbamoyl chlorideHCID 21556048alpha-Carbamylthio2'-chloro-4-biphenylylacetic acidHCID 21556323alpha-Dimethylcarbamylthio-2'-chloro-4-biphenylylacetic acidHCID 54353825alpha-Ethylcarbamylthio-2'-chloro-4-biphenylylacetic acid

Produkt 1

HCID 21556371alpha-Diethylcarbamylthio-2'-chloro-4-biphenylylacetic acid

Versuchsvorschrift

When diethylcarbamylchloride is replaced in the above procedure by carbamyl chloride (prepared in situ from potassium cyanate and anhydrous hydrogen chloride in anhydrous chloroform), ethylcarbamyl chloride or dimethylcarbamyl chloride, then the products prepared are α-carbamylthio2'-chloro-4-biphenylylacetic acid, α-ethylcarbamylthio-2'-chloro-4-biphenylylacetic acid or α-dimethylcarbamylthio-2'-chloro-4-biphenylylacetic acid.

Aufarbeitung

  1. customthe products prepared

Quellen und Nachweise

ORD-Eintrag
ord-92812363b4e14ecfb4da9e08a1558a01
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03941821

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