HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
O-Xylene → 5-Fluoro-2-methylindan-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | O-Xylene | HCID 7237 | — |
| Edukt | Phosphorus oxide (P4O10) | HCID 14812 | — |
| Edukt | 1-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one | HCID 21521891 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 5-Fluoro-2-methylindan-1-one | HCID 3016257 | — |
Reaktionsschritte
A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for one hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US03944600 |
| Quelldatensatz | uspto-grants-1976_03 |
| ORD ID | ord-e35a1b1b9bd74744aba18c195be0050a |
| Quellennotiz | uspto-grants-1976_03 |