反应详情

A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for one hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

1. additionA mixture of 18.2 g
2. temperatureThe reaction is cooled
3. washthe xylene layer is washed with aqueous sodium hydroxide and water
4. concentrationThe organic layer is then concentrated in vacuo