O-Xylene → 5-Fluoro-2-methylindan-1-one

HRID 267822Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 267822
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:13])[CH:9]([CH3:12])[CH2:10]O)=[CH:4][CH:3]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.C1(C)C(C)=CC=CC=1>O>[F:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[C:8](=[O:13])[CH:9]([CH3:12])[CH2:10]2

Komponenten

5

Edukt 3

HCID 7237O-XyleneHCID 14812Phosphorus oxide (P4O10)HCID 215218911-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one

Produkt 1

HCID 30162575-Fluoro-2-methylindan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for one hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

Aufarbeitung

  1. additionA mixture of 18.2 g
  2. temperatureThe reaction is cooled
  3. washthe xylene layer is washed with aqueous sodium hydroxide and water
  4. concentrationThe organic layer is then concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e35a1b1b9bd74744aba18c195be0050a
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03944600

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