Potassium Carbonate → N-(1,3-dioxolan-5-ylmethyl)-2-methyl-6-methoxyaniline

HRID 268052

Reaktionsgleichung

Reaktionsgleichung von HRID 268052
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:3]=1[NH2:4].Cl[CH2:12][CH:13]1[O:17][CH2:16][O:15][CH2:14]1.C(=O)([O-])[O-].[K+].[K+]>[Cl-].C([N+](CC)(CC)CC)C>[O:17]1[CH:13]([CH2:12][NH:4][C:3]2[C:5]([O:9][CH3:10])=[CH:6][CH:7]=[CH:8][C:2]=2[CH3:1])[CH2:14][O:15][CH2:16]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 2401534-(Chloromethyl)-1,3-dioxolaneHCID 4592492-Methoxy-6-methylaniline

Produkt 1

HCID 21447805N-(1,3-dioxolan-5-ylmethyl)-2-methyl-6-methoxyaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5946Tetraethylammonium ChlorideKatalysator

Versuchsvorschrift

2-Methyl-6-methoxyaniline (0.3 mole), 5-chloromethyl-1,3-dioxolane (0.3 mole), potassium carbonate (0.3 mole) and tetraethylammonium chloride (2 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux for a period of 4 hours. After this time the mixture is filtered and distilled to yield the desired product N-(1,3-dioxolan-5-ylmethyl)-2-methyl-6-methoxyaniline.

Aufarbeitung

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux for a period of 4 hours
  5. filtrationAfter this time the mixture is filtered
  6. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-8ddec6bbba5c4402bd66d5f98fa1b0ed
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03946045

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