Tetraethylammonium Chloride (HCID 5946)

Überblick

Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.

Namen und Bezeichner

Bevorzugter Name: Tetraethylammonium Chloride
IUPAC: tetraethylazanium chloride
Lokaler Name: Tetraethylammoniumchlorid
Englischer Name: Tetraethylammonium Chloride
Summenformel: C8H20ClN
Molmasse: 165.7

Namen und Synonyme

TETRAETHYLAMMONIUM CHLORIDE56-34-8Etamon chlorideTea chlorideTEACN,N,N-Triethylethanaminium chlorideEthanaminium, N,N,N-triethyl-, chloridetetraethylazanium;chlorideDTXSID6041137CHEBI:781618B82Z83XNNDTXCID4021137

Weitere Namen anzeigen

TetraethylammoniumtetraethylazaniuM chlorideSKL1479N2,2,2,2Clammonium chLEthamon chlorideTetraethylammonium choride

RefChem:188563Chloride, Tetraethylammonium200-267-5Tetraethyl ammonium chloridetetraethylammoniumchlorideEt4NClTetraethylammonium (chloride)EINECS 200-267-5

Datenbank-Bezeichner

CAS: 56-34-8
PubChem CID: 5946
DTXSID: DTXSID6041137
ChEMBL: CHEMBL434435
ChEBI: CHEBI:78161
UNII: 8B82Z83XNN
EC Number: 200-267-5

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 0 Å²
H-Brücken-Donoren: 0
H-Brücken-Akzeptoren: 1
Frei drehbare Bindungen: 4
Schwere Atome: 10
Formalladung: 0
Komplexität: 47,5

Experimentelle und physikochemische Eigenschaften

Chemical ClassesNitrogen Compounds -> Quaternary Amines

Density1.08 @25 °C

Solubility20.3 [ug/mL] (The mean of the results at pH 7.4)

Vapor Pressure0.00000308 [mmHg]

Physical Description · 2 Einträge

Liquid

Deliquescent solid; [Merck Index] Colorless or light yellow hygroscopic crystals; [Sigma-Aldrich MSDS]

Physikochemische Eigenschaften

Schmelzpunkt: 39 °C · 39°C
Siedepunkt: 273.32 °C · 273.32°C (rough estimate)
Dichte: 1.08 · 1.08
Brechungsindex: 1.548 · 1.5480 (estimate)
storage temp.: Inert atmosphere,Room Temperature
Löslichkeit: 0.1 g/mL, · methanol: 0.1 g/mL, clear, colorless
Aggregatzustand: Crystalline Powder
Farbe: white to light yellow
PH: 4 to · 4.0 to 7.0(50g/L, 25℃)
Biologische Quelle: synthetic (organic)
Wasserlöslichkeit: Soluble in water, ethanol, chloroform, or acetone
Merck: 14 · 14,9200
BRN: 3563247 · 3563247
Stabilität: Stable. Incompatible with strong oxidizing agents. Protect from moisture.
InChI: 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
InChIKey: YMBCJWGVCUEGHA-UHFFFAOYSA-M
SMILES: [Cl-].CC[N+](CC)(CC)CC
CAS Datenbank: 56 · 56-34-8(CAS DataBase Reference)
EPA chemische Informationen: Tetraethylammonium chloride (56-34-8)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

Warning

H302 (25.2%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 103 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: Ethanaminium, N,N,N-triethyl-, chloride (1:1)

Ethanaminium, N,N,N-triethyl-, chloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanaminium, N,N,N-triethyl-, chloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 06-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/20036

Ethanaminium, N,N,N-triethyl-, chloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Tetraethylammonium salts: Human health tier II assessment

Hazards Summary · 1 Eintrag

Causes somnolence, tremor, and muscle weakness in oral, intraperitoneal, and intramuscular lethal-dose studies of mice and rats; Human intravenous injection of 5 mg/kg causes paresthesias, mydriasis, and ptosis; [RTECS] A skin and strong eye irritant; Targets the heart and CNS; [Sigma-Aldrich MSDS] See Tetraethylammonium bromide.

Hazard Classes and Categories · 2 Einträge

Acute Tox. 4 (25.2%)

Eye irritation - category 2B

Sicherheit und Schutzausrüstung

Protective Action Criteria (PAC) · 3 Einträge

0.55 [mg/m3]

6.0 [mg/m3]

30 [mg/m3]

Toxikologische Informationen

Adverse EffectsNeurotoxin - Other CNS neurotoxin

Sicherheitsdaten

F: 3-10
wgk: 3
tsca: TSCA listed
hs_code: 29239000
RTECS-Nr.: BS6125000
risk_code: 22-36/37/38
Toxizität: LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)
hazard_code: Xn,Xi
safety_code: 26-36-37/39
Speicherklasse: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological ClassificationA class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.

Verwendung und Herstellung

UsesUsed as a catalyst (dehydrogenation and polymerization) and electrolyte (membrane transport studies); [Merck Index]

U.S. Production2023: 1,000,000 - <5,000,000 lb

Industry UsesIntermediate

General Manufacturing Information · 2 Einträge

All Other Basic Organic Chemical Manufacturing

Ethanaminium, N,N,N-triethyl-, chloride (1:1): ACTIVE

Anwendungen · 1 Eintrag

VerwendenTetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.

Vor- und nachgelagerte Produkte

Nachgelagerte Produkte

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Ergänzende Hinweise · 1 Eintrag

DefinitionChEBI: Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.