3-Nitrobenzaldehyde → 2-Amino-4-(3-nitrophenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3-Nitrobenzaldehyde	HCID 7449	—
Edukt	1,3-Cyclohexanedione	HCID 10434	—
Edukt	Carbamimidoyl-acetic acid ethyl ester	HCID 4599837	—
Produkt	2-Amino-4-(3-nitrophenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester	HCID 12391117	61%

Reaktionsschritte

Upon boiling a solution of 7.6 g of 3-nitrobenzaldehyde, 5.6 g of cyclohexane-1,3-dione and 6.5 g of amidinoacetic acid ethyl ester for 1 hour, 2-amino-4-(3-nitrophenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point >260°C is obtained (alcohol/DMF).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US03946026
Quelldatensatz	uspto-grants-1976_03
ORD ID	ord-556dbc3536db49deb7722411c358dd5e
Quellennotiz	uspto-grants-1976_03