Sulfuryl chloride → Ethyl 2-chloro-3-oxopentanoate

HRID 26820

Reaktionsgleichung

Reaktionsgleichung von HRID 26820
S(Cl)([Cl:4])(=O)=O.[O:6]=[C:7]([CH2:14][CH3:15])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(Cl)(Cl)Cl>[Cl:4][CH:8]([C:7](=[O:6])[CH2:14][CH3:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10]

Komponenten

4

Edukt 2

HCID 24648Sulfuryl chlorideHCID 78656Ethyl 3-oxovalerate

Produkt 1

HCID 12923424Ethyl 2-chloro-3-oxopentanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hours and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.

Aufarbeitung

  1. additionaddition the mixture
  2. temperatureheated
  3. temperatureunder reflux for 0.5 hours
  4. temperaturecooled
  5. washAfter washing with water, sodium bicarbonate and water
  6. dry with materialthe solution was dried (sodium sulphate)
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c5cafc11c6b1484381f814e313447934
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04151288

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