Formaldehyde → (3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

HRID 268240

Reaktionsgleichung

Reaktionsgleichung von HRID 268240
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[CH2:11]=O.[CH:13]1[CH:14]=[C:15]2[C:20]3=[C:21]([C:23]([NH:25][C:26](=[O:27])[C:19]3=[CH:18][CH:17]=[CH:16]2)=[O:24])[CH:22]=1>CN(C)C=O>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][N:25]1[C:26](=[O:27])[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:20]=2[C:21](=[CH:22][CH:13]=[CH:14]3)[C:23]1=[O:24]

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 70461,2,3,4-TetrahydroisoquinolineHCID 66491Naphthalimide

Produkt 1

HCID 21551797(3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

An equimolar mixture of 1,2,3,4-tetrahydroisoquinoline, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield 2-[(3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione.

Aufarbeitung

  1. temperaturethe mixture is heated until dissolution
  2. customto stand at room temperature
  3. filtrationthe resulting precipitate is filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-86ae842f9f6b4d99be980a88a6d2904a
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03947452

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