Triethylamine → HCID 23104300, Verbindung

HRID 268568

Reaktionsgleichung

Reaktionsgleichung von HRID 268568
F[C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([CH3:8])[CH:7]=1.CN1CCCC1=O.[NH2:19][CH2:20][CH2:21][CH:22]([OH:24])[CH3:23].C(N(CC)CC)C>O>[N+:9]([C:5]1[CH:4]=[CH:3][C:2]([NH:19][CH2:20][CH2:21][CH:22]([OH:24])[CH3:23])=[CH:7][C:6]=1[CH3:8])([O-:11])=[O:10]

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 949565-Fluoro-2-nitrotolueneHCID 1702542-Butanol, 4-amino-

Produkt 1

HCID 23104300HCID 23104300, VerbindungAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

2 g of 5-fluoro-2-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.38 g of 4-amino-2-butanol and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 10 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 2.88 g of 4-(4-nitro-3-methylphenylamino)butan-2-ol (31) were obtained.

Aufarbeitung

  1. temperatureafter cooling to room temperature
  2. extractionThe resulting medium was extracted with ethyl acetate
  3. concentrationthe organic phase was then concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-06ad4cc3d0ec4d17b0de31598f582ee1
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07445645B2

Verknüpfte Notizen

Wird geladen…