3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid

HRID 26922

Reaktionsgleichung

Reaktionsgleichung von HRID 26922
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:20])=[CH:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1>O=[Pt]=O.O1CCOCC1>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:20])[CH2:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1

Komponenten

4

Edukt 1

HCID 540100683-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid

Produkt 1

HCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

1 g. of 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid is dissolved in 25 ml. of dioxane. 0.1 g. of PtO2 is added and the hydrogenation is carried out at 20° under normal pressure until hydrogen absorption has ceased. The mixture is filtered and the filtrate is evaporated to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

Aufarbeitung

  1. customthe hydrogenation is carried out at 20° under normal pressure until hydrogen absorption
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-0147196874c445caa05e8ce4ff012648
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04151302

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