Water → 2-Benzyloxy-[1,1';2',1'']terphenyl-3''-carboxylic acid
Reaktionsgleichung
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:9]=[CH:10][CH:11]=1)=[O:5])C.[OH-].[Na+].O>C(O)C>[CH2:25]([O:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:13]1[C:12]([C:8]2[CH:9]=[CH:10][CH:11]=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=2)=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
2-Benzyloxy-[1,1′;2′,1″]terphenyl-3″-carboxylic acid ethyl ester (84 mg, 0.206 mmol) was dissolved in ethanol (2 ml) and 2M sodium hydroxide (0.5 ml) added. The mixture was stirred and heated to 50° C. for 4 h. Water was added and the mixture extracted with isohexane. The aqueous layer was acidified with 2M hydrochloric acid and extracted with diethyl ether (2×10 ml). The combined organic phases were washed with water, dried (MgSO4) and evaporated. The oil was triturated with isohexane and the resulting white solid filtered, washed with isohexane and dried in vacuo. (42 mg, 54%).
Aufarbeitung
- extractionthe mixture extracted with isohexane
- extractionextracted with diethyl ether (2×10 ml)
- washThe combined organic phases were washed with water
- dry with materialdried (MgSO4)
- customevaporated
- customThe oil was triturated with isohexane
- filtrationthe resulting white solid filtered
- washwashed with isohexane
- customdried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-d92563337723441e9c318ae746aa1691
- Quelldatensatz
- uspto-grants-2008_11
- Patentnummer
- US07446222B2
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