Triethylamine → (2S)-2,4-Bis[(tert-butoxycarbonyl)amino]butyl methanesulphonate

HRID 269617Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 269617
[C:1]([O:5][C:6](=[O:21])[NH:7][CH2:8][CH2:9][C@H:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][OH:12])([CH3:4])([CH3:3])[CH3:2].[CH3:22][S:23](Cl)(=[O:25])=[O:24].C(N(CC)CC)C>ClCCl>[CH3:22][S:23]([O:12][CH2:11][C@@H:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:9][CH2:8][NH:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:21])(=[O:25])=[O:24]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 57440192HCID 57440192, Verbindung

Produkt 1

HCID 86601681(2S)-2,4-Bis[(tert-butoxycarbonyl)amino]butyl methanesulphonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Preparation takes place in analogy to Example 84A from 250 mg (0.81 mmol) of tert-butyl{(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutyl}carbamate (Example 89A) in 20 ml of dichloromethane with 110 mg (0.97 mmol) of methanesulfonyl chloride and 0.23 ml (1.6 mmol) of triethylamine. The product is reacted without further purification.

Aufarbeitung

  1. customPreparation
  2. customThe product is reacted without further purification

Quellen und Nachweise

ORD-Eintrag
ord-66dc4b91028b4aafb09346fd1ff872a6
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446102B2

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