Cyclopropylamine → N-Cyclopropyl-4-fluoro-2-hydroxybenzamide

HRID 270063Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 270063
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[C:4]([OH:12])[CH:3]=1.[CH:13]1([NH2:16])[CH2:15][CH2:14]1>>[CH:13]1([NH:16][C:6](=[O:8])[C:5]2[CH:10]=[CH:11][C:2]([F:1])=[CH:3][C:4]=2[OH:12])[CH2:15][CH2:14]1

Komponenten

3

Edukt 2

HCID 69828CyclopropylamineHCID 2775386Methyl 4-fluorosalicylate

Produkt 1

HCID 68961144N-Cyclopropyl-4-fluoro-2-hydroxybenzamide

Versuchsvorschrift

A suspension of methyl 4-fluoro-2-hydroxybenzoate (510 mg, 3.0 mmol) in cyclopropylamine (5 mL) was stirred at room temperature overnight when it became a clear solution. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum ether) to give the subtitled compound (493 mg).

Aufarbeitung

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum ether)

Quellen und Nachweise

ORD-Eintrag
ord-bf55cd4353ca46b28da7938e0e45cb3d
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07449475B2

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