Acetic Anhydride → N-(4-Chloro-2-hydroxyphenyl)acetamide

HRID 270073

Reaktionsgleichung

Reaktionsgleichung von HRID 270073
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CO>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:10](=[O:12])[CH3:11])=[C:3]([OH:9])[CH:4]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 915912-Amino-5-chlorophenol

Produkt 1

HCID 177739N-(4-Chloro-2-hydroxyphenyl)acetamideAusbeute 91,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a suspension of 2-amino-5-chlorophenol (1.01 g, 7.0 mmol) in methanol (10 mL) was added acetic anhydride (1.08 g, 10.55 mmol) and the reaction mixture was stirred at room temperature for 30 min. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (hexane:ethyl acetate 5:2) to give the subtitled compound (1.19 g).

Aufarbeitung

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (hexane:ethyl acetate 5:2)

Quellen und Nachweise

ORD-Eintrag
ord-c24fa62b13a64ab6b70ce5338142fb9d
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07449475B2

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