Methyl Salicylate → N-Methylsalicylamide

HRID 270101

Reaktionsgleichung

Reaktionsgleichung von HRID 270101
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH3:12][NH2:13]>CO>[OH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([NH:13][CH3:12])=[O:10]

Komponenten

4

Edukt 2

HCID 4133Methyl SalicylateHCID 6329Methylamine

Produkt 1

HCID 74624N-MethylsalicylamideAusbeute 90,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of methyl salicylate (5.16 mL, 40 mmol) in methanol (10 mL) was added dropwise to aqueous 40% methylamine (18.1 mL, 210 mmol) at 0° C. After addition was complete the reaction mixture was kept on stirring at room temperature overnight. The volatiles were removed in vacuo to give the subtitled compound (5.48 g).

Aufarbeitung

  1. additionAfter addition
  2. customThe volatiles were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6df448f464b946efb1c50dd83b17c1f4
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07449475B2

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