Dimethylformamide → HCID 178434610, Verbindung

HRID 270786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 270786
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([F:10])([F:9])[F:8])[NH:4][N:3]=1.CN(C=O)C.[Cl:16]N1C(=O)CCC1=O>O>[Cl:16][C:6]1[C:2]([CH3:1])=[N:3][NH:4][C:5]=1[C:7]([F:10])([F:9])[F:8]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 31398ChlorosuccinimideHCID 1390771H-Pyrazole, 3-methyl-5-(trifluoromethyl)-

Produkt 1

HCID 178434610HCID 178434610, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

3-methyl-5-trifluoromethylpyrazole was taken into dry DMF (20 mL) and N-chloro succinimide (1.78 g) was added in portions. The mixture was then heated at 70° C. for 22 h, cooled to room temperature, and then water (100 mL) was added and the mixture extracted with ethyl acetate (4×25 mL). The organic layer was washed with water and brine and dried with Na2SO4. Evaporation of the solvent afforded the title compound.

Aufarbeitung

  1. additionwas added in portions
  2. temperaturecooled to room temperature
  3. extractionthe mixture extracted with ethyl acetate (4×25 mL)
  4. washThe organic layer was washed with water and brine
  5. dry with materialdried with Na2SO4
  6. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-54f8eead3ef64bd1b4ef90c1484c3d55
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07449576B1

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