Cyclohexyl methyl ketone → 1-Cyclohexyl-3-dimethylamino-propenone

HRID 270947

Reaktionsgleichung

Reaktionsgleichung von HRID 270947
[CH3:1][C:2]([CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=O.C([O:14][CH:15](N(C)C)[N:16]([CH3:18])[CH3:17])(C)(C)C>>[CH3:17][N:16]([C:15](/[CH:1]=[CH:2]/[CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:14])[CH3:18]

Komponenten

3

Edukt 2

HCID 13207Cyclohexyl methyl ketoneHCID 79885tert-Butoxy bis(dimethylamino)methane

Produkt 1

HCID 110952411-Cyclohexyl-3-dimethylamino-propenoneAusbeute 93 %

Versuchsvorschrift

A mixture of 3.0 g (23.8 mmol) of cyclohexyl methyl ketone and 4.56 g (26.2 mmol) of t-butoxybis(dimethylamino)methane (Bredereck's reagent) was stirred at 60□C overnight. The reaction mixture was then concentrated to give 4.0 g (93% yield) of 1-cyclohexyl-3-dimethylamino-propenone as an orange oil as indicated by 1H NMR. This product was used in the next reaction without any further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated

Quellen und Nachweise

ORD-Eintrag
ord-3a3f23ec32f84465a1fab219ed0a5fba
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07449488B2

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