Butyl isocyanate → 2-Amino-N-n-butyl-6-(2-furyl)-9H-purine-9-carboxamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A solution of 6-(2-furyl)-1H-purine-2-amine (0.050 g, 0.25 mmol) and DMAP (5 mg, 0.03 mmol) in anhydrous DMF (1 μL) was treated with n-butylisocyanate (0.029 g, 0.30 mmol), shaken at 65° C. for 1 h, poured onto ice-cold water (10 mL), cooled at 0° C. for 15 min and the resulting precipitate filtered and dried in vacuo over P2O5 to give the title compound (74 mg, 100%) as a white solid.

Herkunft & Nachweise