反应详情

温度

65 °C

A solution of 6-(2-furyl)-1H-purine-2-amine (0.050 g, 0.25 mmol) and DMAP (5 mg, 0.03 mmol) in anhydrous DMF (1 μL) was treated with n-butylisocyanate (0.029 g, 0.30 mmol), shaken at 65° C. for 1 h, poured onto ice-cold water (10 mL), cooled at 0° C. for 15 min and the resulting precipitate filtered and dried in vacuo over P2O5 to give the title compound (74 mg, 100%) as a white solid.

1. additionpoured onto ice-cold water (10 mL)
2. temperaturecooled at 0° C. for 15 min
3. filtrationthe resulting precipitate filtered
4. dry with materialdried in vacuo over P2O5