Isopropylamine → HCID 58772830, Verbindung

HRID 271449Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 271449
Cl[C:2]1[N:7]2[C:8](=[O:11])[NH:9][N:10]=[C:6]2[C:5]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[C:4]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[N:3]=1.[CH:26]([NH2:29])([CH3:28])[CH3:27]>C1COCC1>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([C:4]2[N:3]=[C:2]([NH:29][CH:26]([CH3:28])[CH3:27])[N:7]3[C:8](=[O:11])[NH:9][N:10]=[C:6]3[C:5]=2[C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[CH:20][CH:21]=1

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 587728405-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one

Produkt 1

HCID 58772830HCID 58772830, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirring solution of 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one (39 mg, 0.10 mmol) in 1 mL THF, was added isopropylamine (18 mg, 0.30 mmol). The reaction mixture was stirred at room temperature for 1 h and then concentrated under reduced pressure. The resulting crude title compound was used in the next step without further purification.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. customThe resulting crude title compound was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-fe6ed3745cb84b19b8d45685c6afdf0d
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452892B2

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